Tuesday, June 7, 2016

ANSWER- 3 107 TO 160

107. Prevention and management of eclampsia.
The management of pre-eclampsia should begin at the first sign
of abnormality, well before the diagnosis is confirmed. When excessive weight gain or fluid retention is documented in the absence of other pathognomonic changes, a brief dietary history should be
obtained to look for indiscretions and excesses. Appropriate
counseling should follow. The patient should be advised of any concerns
and be requested to increase periods of bed rest, preferably in
the left lateral position. For the following 48 hours, activity out of bed
should be limited to eating meals (not preparing them) and using the
bathroom. A no-added-salt diet may be prescribed. More Severe
sodium restriction is contraindicated for all but those in frank renal
failure. Follow-up is requested 48 hours or less later to ton-firm
continued normal blood pressure and to determine the efficacy of
treatment for the weight gain and fluid retention. Successful treatment
dictates no further intervention, other than perhaps the continuation of
the no-added-salt diet. If there has been no weight loss, continued
reduction of activity with increased periods of bed rest and more
frequent prenatal visits are indicated.
The treatment of hypertension depends to a great extent on the
duration of the pregnancy and the elevation of blood pressure. At the
lowest end of the hypertensive spectrum, 140/90 mm Hg, and in
the absence of proteinuria, outpatient management is possible.
Mild salt reduction (no added salt) and bed rest in the left lateral
position are again advised. The patient and her family should be
counseled regarding warning symptoms of deterioration. Follow-up
should occur no later than 48 hours. Many patients in this category
respond to bed rest with a normalization of blood pressure. These
women merely require more frequent follow-up than usual.
For the nonresponders, the next step should be a trial of bed rest
and a no-added-salt diet in the more controlled environment of the
hospital. If blood pressure normalizes, observation should be
continued for an additional 24 to 48 hours and the patient should
follow a regimen of continued bed rest and diet with frequent followup.
Nonresponders who are 37 weeks' gestation or greater should be
evaluated for induction of labor. Those at less than 37 weeks' gestation
should continue bed rest and diet in the hospital for several days while
undergoing the work-up detailed in Table. Patients with continued
mild hypertension (not greater than 150/100 mm Hg) without
proteinuria and with normal laboratory values may be considered for discharge and close follow-up.

108. Management of nephropathy.
Pregnant patients with kidney disease are often under the care of a maternal-fetal specialist who has advanced training in high-risk obstetrics. These patients receive frequent obstetric follow-up that includes careful blood pressure monitoring, renal function testing, and 24-hour urine protein collections. Consultation with a nephrologist often occurs, particularly for patients with more advanced disease and those with progressive renal failure.
Almost all patients with significant renal disease and/or hypertension in late pregnancy, or when the likelihood of fetal viability is very high, are delivered and they can be managed as non-gravid patients. If progressive renal failure occurs either in early pregnancy or before fetal viability can be assured, however, dialysis may need to be considered.
Dialysis should be initiated when the serum creatinine level is 3.5-5.0 mg/dL or the glomerular filtration rate (GFR) is below 20 ml/min. Fetal outcome is improved with longer, more frequent hemodialysis sessions, which usually involves 20 hours of dialysis per week. Daily dialysis is more likely to prevent hypotension and significant metabolic shifts.
Dialysis should aim to keep blood urea nitrogen levels below 50 mg/dL, because controlling uremia may avoid polyhydramnios, control hypertension, and improve the mother's nutritional status. Peritoneal dialysis with smaller volumes and frequent exchanges can also be done to achieve these same goals.
Anemia should be treated with erythropoietin and careful attention to iron therapy. Nutritional support that allows weight gains of 0.3 to 0.5 kg/wk should be maintained in the second and third trimesters.
Pregnancy in patients receiving dialysis
Although fertility is significantly impaired in women with end-stage renal disease, pregnancy may still occur.[14] Most women on dialysis are anovulatory, with either irregular or no menses, which can result in significant delays in the diagnosis of pregnancy in those who do conceive. In addition, the spontaneous abortion rate for pregnant women who require dialysis is approximately 50%. For pregnancies that continue, however, the fetal survival rate is as high as 71%.
Pregnancy in women with kidney transplants
Pregnancy in women following renal transplantation has become commonplace. Transplantation restores fertility, and although most women with kidney transplants can deliver successfully, there is a higher risk of miscarriage, therapeutic abortion, stillbirth, ectopic pregnancy, preterm birth, low birthweight babies, and neonatal death.
Guidelines for pregnancy in kidney transplant recipients include the following
·         Good general health for 2 years post-transplantation, with serum creatinine levels below 2.0 mg/dL (preferably < 1.5 mg/dL)
·         No recent acute rejection or ongoing rejection
·         Normotension, or hypertension controlled with minimal antihypertensive agents
·         No or minimal proteinuria
·         No evidence of pelvicaliceal dilatation on renal ultrasonogram
Recommended immunosuppression in kidney transplant recipients includes:
·         Prednisone – Less than 15 mg per day (mg/d)
·         Azathioprine – 2 mg/kg/d or less
·         Calcineurin inhibitor–based therapy at appropriate therapeutic levels
·         Breast-feeding on cyclosporine is not recommended; tacrolimus may be taken during breast-feeding though monitoring of infant levels is recommended.
·         Mycophenolate mofetil and sirolimus should be discontinued for 6 weeks prior to conception
·         If necessary, methylprednisolone is the preferred agent for treatment of rejection should it occur during pregnancy
The following are complication risks in kidney transplant recipients:
·         Immunosuppressive agents increase the risk of hypertension during pregnancy
·         Preeclampsia occurs in approximately one third of kidney-transplant recipients
·         Almost 50% of pregnancies in these women end in preterm delivery due to hypertension
·         Blood levels of calcineurin inhibitors need to be frequently monitored due to changes in volumes of distribution of extracellular volume
·         There is an increased risk of cytomegalovirus, toxoplasmosis, and herpes infections, which raise concern for the fetus

109. Transverse and oblique fetal positions. Course and outcomes of labor.
Note: Guys I added a bit from malpresentation, I couldn’t find everything

With transverse and oblique lies, the shoulder structures (acromion) can be used for the description of position. The incidence of transverse lie has been reported as 0.3%.2 Fetal malformations can cause these (and other) malpresentations. These two types of lies have been associated with grandparity, contracted maternal pelvis, placenta previa, prematurity, polyhydramnios, and uterine abnormalities such as transverse septum or leiomyomas. A patient in her last month of pregnancy with a fetus in a transverse or oblique lie would require an ultrasound and physical examination for the evaluation of any of the above risk factors. If no contraindications are identified, one possible management alternative would be an external cephalic version. The success of external cephalic version in cases of transverse lie has been reported as high as 83%,3 even when performed intrapartum. If an elective cesarean section is to be performed, it should be scheduled for the last week of the pregnancy, because 83% of transverse lies will spontaneously convert to a vertex presentation before 39 weeks.4 This expectant management has to be individualized. Patients showing signs of early labor or those with cervical dilation are candidates for an attempt of external version or delivery by cesarean section before 39 weeks.

Vital to good progress in labour is the tight application of the fetal presenting part on to the cervix. Face presentations may apply themselves poorly to the cervix and the resulting progress in labour may be poor, although vaginal birth is still possible. Brow presentations are associated with the mento-vertical diameter, which is simply too large to fi t through the bony pelvis unless fl exion occurs or hyperextension to a face presentation. Brow presentation therefore often manifests as poor progress in fi rst stage, often in a multiparous woman. Shoulder presentations cannot deliver vaginally and once again poor progress will occur. Malpresentations are more common in women of high parity and some carry a risk of uterine rupture
if the labour is allowed to continue.


110. Obstetric analgesia. Use of medications, electroanalgesia, acupuncture.

Analgesic and Anesthetic Techniques for Obstetrics
Labor and Delivery

Nonpharmacologic
Lamaze
Leboyer
Acupuncture
Hypnosis
Massage
Warm baths

Regional Analgesia/Anesthesia
Local infiltration for episiotomy (lidocaine)
Epidural (bupivacaine)
Spinal (tetracaine, bupivacaine, or
lidocaine)
Caudal
Paracervical
Pudendal (lidocaine)

Systemic Medication
Narcotics (fentanyl)
Sedativ-tranquilizers (Phenergan)

Inhalation Analgesia
Nitrous oxide
Penthran
Ethran

Cesarean Section

Regional Anesthesia
Epidural (lidoraine, chloroprocaine, or
bupivacaine)
Spinal (tetracaine, bupivacaine, or
lidocaine)
Pudendal nerve block

General Anesthesia
Although all drugs cross the placenta to some extent, the degree of
transfer is determined by maternal and fetal blood flow to the placenta as well as by factors that determine drug passage across the placental barrier itself.
These inhalation anesthetics produce a dose-dependent decrease in
uterine resting tone, uterine contractility, and uterine responsiveness to oxytocin.
During the active phase of the first stage of labor, epidural analgesia
has either no significant effect or causes enhanced uterine activity.
Excessive anesthesia during the first stage of labor relaxes the pelvic
floor musculature and may cause mal-rotation by interfering with
internal rotation of the fetal head. In the parturient who is motivated to bear down and is properly instructed, the appropriate use of regional anesthesia without excessive motor blockade should not prolong the second stage of labor.
  
Electroanalgesia
Transcutaneous electrical nerve stimulation TENS uses the gate theory of pain control and, by application of an
electrical current to the nerves carrying the painful stimuli, transmission of pain is partially blocked. Skin surface
electrodes (Fig. 1) are used to apply a low voltage electrical current, which is modified by the patient. These are usually applied across the lower back covering the T10-L1 nerve roots (theinnervation of the uterus) early in the first stage for optimum effect. Although concern has been expressed
about the use of TENS applied over the lower abdomen as the electrical activity may theoretically have an effect
on the fetal heart, no adverse effect has been documented.



111. Clinic and management of placental abruption.

Clinic
Placental abruption typically presents as vaginal bleeding associated with pain. The pain can be constant, or as frequent short-lasting contractions caused by the irritable effect of blood within
the uterus. The patient may report reduced fetal movements and the cardiotocograph may demonstrate a non-reassuring fetal heart rate pattern. Constant pain associated with a uterus that is very
hard on palpation is known as a Couvelaire uterus and is due to a large volume of blood within the myometrium.


Management of placental abruption
The patient should be initially resuscitated using the structured approach of ABC. Management depends on recognition of the problem, realization that true blood loss may be far greater than the
blood loss seen, and rapid institution of major haemorrhage management. In very severe cases, the fetus will be dead and vaginal delivery can be accelerated by artificial rupture of the membranes once the mother is reasonably stable. If the fetus is alive, delivery without compromising the mother’s resuscitation is urgent and this will usually be by Caesarean section.

112. Prevention and management of uterus’ ruptures.
  
Prevention






113. Decapitation (indications, conditions, technique).


DECAPITATION 
Definition
It is a destructive operation where by the fetal head is severed from the trunk and the delivery is completed with the extraction of the trunk and that of the decapitated head per vaginam.
Indication
      Neglected shoulder presentation with dead fetus where neck is easily assessable
      Interlocking head of the twins
Procedure
The operation should be done at general anesthesia
Actual step
Step 1 :- if the fetal hand is not prolapsed bring down the hand. A roller gauze is tied on the fetal wrist and assistant is asked to give the traction towards the side away from the fetal head to make the neck more assessable and fixed
Step 2 :- two fingers of the left hand are introduced with the palmar surface downwards and the finger tips are to be placed on the superior surface of the neck –the prolapsed site of decapitation.
Step 3 :- the decapitation hook with knife is to be introduced flushed under the guidance of the fingers placed in to the vagina, trhe knob pointing toward the fetal head. The hook is pushed above the neck and rotated to 90 ̊ , so as to placed the knife firmly against the neck.
Step 4 :- by upward and downward movement of the hook with knife the vertebral column is severed.
Step 5:- delivery of the decapitation head – the methods are
  • By hooking the index fingers into the mouth
  • By holding the severed head with Giant Vulsellum and delivery of he head as that of aftercoming head in breech.
  • Using forceps
Step 6 :- routine exploration of the utero vaginal canal to exclude rupture of the uterus or any other injury.




114. Flat pelvis. Mechanisms of labor.

                        Normal mechanism of labour
As the fetus descends through the birth canal, it undergoes changes in position and attitude, in order to pass through the pelvis. In a typical (gynaecoid) pelvis, the transverse diameter (13 cm) is wider than the anteroposterior diameter (11 cm) at the pelvic inlet. The mid-cavity is circular in cross-section (12 cm diameter). At the pelvic outlet the AP diameter (13.5 cm) iswider than the transverse (11 cm).

ENGAGEMENT The fetal head enters the pelvis in the OT position. The head is engaged when the widest part of the presenting part has passed through the inlet (<2/5 palpable abdominally). This occurs prior to labour in nulliparous women (although not necessarily in multiparous women).

DESCENT Descent occurs with uterine contractions.

FLEXION As the head enters the midcavity, it flexes (chin touching chest), remaining in the OT position.

INTERNAL ROTATION As the head reaches the pelvic outlet it encounters the levator ani muscles of the pelvic floor and rotates to the OA position.

EXTENSION The head descends beyond the ischial spines. Upward pressure from the pelvic floor causes the head to extend.

CROWNING The occiput emerges from underneath the symphysis pubis and distends the vulva.

EXTERNAL ROTATION The shoulders now rotate into an oblique or frank anterior/posterior plane.

RESTITUTION The head now aligns itself with the shoulders and delivery occurs.









115. Management of the second stage of labor.







Clinical Management of the Second Stage
As in the first stage, certain steps should be taken in the clinical
management of the second stage of labor.
Maternal Position. With the exception of avoiding the supine
position, the mother may assume any comfortable position for
effective bearing down. If the birth is to occur in another room,
primiparous patients should be moved at or before the beginning of crowning. Multiparous patients should be brought to the delivery room at the time of complete cervical dilation.
Bearing Down. With each contraction, the mother should be
encouraged to hold her breath and bear down with expulsive efforts. This is particularly important for patients with regional anesthesia because their reflex sensations may be impaired.
Fetal Monitoring. During the second stage, the fetal heart rate
should be monitored continuously or evaluated every 5 minutes in
patients with obstetric risk factors. Fetal heart rate decelerations (head compression or cord compression) with recovery following the uterine contraction may normally occur during this stage.
Vaginal Examination. Progress should be recorded
approximately every 30 minutes during the second stage. Particular attention should be paid to the descent and flexion of the presenting part, the extent of internal rotation, and the development of molding or caput.


116. Diagnostic of early terms of pregnancy.

The diagnosis of pregnancy requires a multifaceted approach using 3 main diagnostic tools. These are history and physical examination, laboratory evaluation, and ultrasonography.

History: The woman should describe her usual menstrual pattern, including date of onset of last menses, duration, flow, and frequency. Items that may confuse the diagnosis of early pregnancy are an atypical last menstrual period, contraceptive use, and a history of irregular menses.

physical examination: Upon physical examination, one may find an enlarged uterus after bimanual examination, breast changes, and softening and enlargement of the cervix (Hegar sign; observed at approximately 6 wk). The Chadwick sign is a bluish discoloration of the cervix from venous congestion and can be observed by 8-10 weeks. A gravid uterus may be palpable low in the abdomen if the pregnancy has progressed far enough, usually by 12 weeks.

laboratory evaluation: assessment of human chorionic gonadotropin (hCG) in urine or blood.

ultrasonography


117. Puerperium. Course and management.

Puerperium
The puerperium consists of the period following delivery of the
baby and placenta to approximately 6 weeks postpartum. During the puerperium, the reproductive organs and maternal physiology return toward the prepregnancy state although menses may not return for much longer.

Anatomic and Physiologic Changes
Involution of the Uterus
Through a process of tissue catabolism, the uterus rapidly
decreases in weight from about 1000 g at delivery to 100 to 200 g at approximately 3 weeks postpartum. The cervix similarly loses its
elasticity and regains its prepregnancy firmness. For the first few days after delivery, the uterine discharge (lochia) appears red (lochia rubra) owing to the presence of erythrocytes. After 3 to 4 days, the lochia becomes paler (lochia serosal, and by the tenth day, it assumes a white or yellow-white color (lochia alba). Foul-smelling lochia suggests, but is not diagnostic of, endometritis.
Vagina
Although the vagina may never return to its prepregnancy state,
the supportive tissues of the pelvic floor gradually regain their former tone.
Cardiovascular System
Immediately following delivery, there is a marked increase in
peripheral vascular resistance due to the removal of the low-pressure uteroplacental circulatory shunt. The cardiac output and plasma volume gradually return to normal during the first 2 weeks of the puerperium. As a result of the loss of plasma volume and the diuresis of extracellular fluid, a marked weight loss occurs in the first week. A significant granulocytic leukocytosis may be seen in the immediate
postpartum period.
Psychosocial Changes
It is fairly common for women to exhibit a mild degree of
depression a few days following delivery. The "postpartum blues" are probably due to both emotional and hormonal factors. With understanding and reassurance from both family and physician, this usually resolves without consequence.
Return of Menstruation and Ovulation
In women who do not nurse, menstrual flow will usually return
by 6 to 8 weeks following delivery, although this is highly variable.
Although ovulation may not occur for several months, particularly in nursing mothers, contraceptive counseling and use should be
emphasized during the puerperium to avoid an undesired pregnancy.

Management
Management of normal puerperium
Immediately following delivery, the patient should be closely observed. She may be given
a drink of her choice or something to eat, if she is hungry.

Principles -
- To give all out attention in to restore the health status of the mother.
- To prevent infection.
- To take care of the breasts, including promotion of lactation and nursing of the child.
- To motivate the mother for contraception.

General management -

Rest and ambulance -
It is indeed difficult to categories an uniform period of rest. After a good resting period,
the patient becomes fresh and can breast feed the baby or moves out of bed to go to the
toilet. Early ambulation is encouraged.

Que. - What is the benefits of early ambulation after delivery ?
Ans. -  Advantages of early ambulation are:
           - Provide a sense of well-being.
           - Bladder complications and constipation are reduced.
           - Facilitates uterine drainage.
           - Hastens involution of uterus.
           - Lessens puerperal venous thrombosis and embolism.

Hospital stay -
Early discharge from the hospital is an almost universal procedure. If adequate supervision
by trained health visitors is provided, there is no harm in early discharge.

Diet -
The patient should be on normal diet of her choice. If the patient is lactating, high calories,
adequate protein, fat, plenty of fluids, minerals and vitamins are to be given.

Care of the bladder -
The patient is encouraged to pass urine following delivery as soon as convenient. If the patient
fails to pass urine, catheterisation should be done. Catheterisation is also indicated in case of
incomplete emptying of bladder.

Care of the bawel -
The problem of constipation is much less because of early ambulation and liberalisation of the
dietary intake. A diet containing sufficient roughage and fluids is enough to move the bowel.
If necessary, mild laxative such as Igol (isopgol husk) two teaspoons may be given at bed time.

Sleep -
The patient is in need of rest, both physical and mental. So she should be protected against
worries and undue fatigue. Sleep is ensured providing adequate physical and emotional support.

Care of the vulva and episiotomy -
Shortly after delivery, the vulva and buttocks are washed with soapwater down over the anus
and a sterile pad is applied. The patient should look after personal cleanliness of the vulval
region. The perineal wound should be dressed with spirit and antiseptic power after each act
micturition and defaecation or at least twice a day.

Care of the breast -
The nipple should be washed with sterile water before each feeding. It should be cleaned
and kept dry after the feeding is over. Nipple soreness is avoided by frequent short feeding
rather than the prolonged feeding, keeping the nipple clean and dry.

Maternal-infant bonding -
It starts from first few moments after birth. This is manifested by fording, kissing, cuddling
and gazing at the infant. The baby should be kept in her bed or in a cot besides her bed.
This is not only establishes the mother-child relationship but the mother is conversant with
the art of baby care so that she can take full care of the baby while at home.

Asepsis and antiseptic -
Asepsis must be maintained specially during the first week of puerperium. Liberal use of
local antiseptics, aseptic measures during perineal wound dressing, use of clean bed linen
and clothing are positive steps.

Immunization -
Administration of anti-D-gamma globulin to unimmunized Rh-negative mother bearing
Rh-positive baby. The booster dose of tetanus toxoid should be given at the time of
discharge, if it is not given during pregnancy.






118. Pregnancy and congenital heart diseases.

Management of specific cardiac lesions in pregnancy
1. Atrial septal defect. This is the most common heart lesion
complicating preg nancy.
- Hemodynamic effects. Most patients are asymptomatic, and the
lesion is discovered by auscultation of a murmur. The left-to-right
shunting will cause an increase in pulmonary blood flow, but
pulmonary hypertension is a relatively late finding.
- Effect of pregnancy. In the absence of pulmonary hypertension,
this lesion is well tolerated in pregnancy and should not threaten
maternal health. If the patient has experienced pulmonary
hypertension, then she is at risk for Eisenmenger's syndrome, a
diagnosis that carries a maternal mortality of 50%. Therefore, in
counseling the patient with an atrial septal defect (ASD), it is critical
to evaluate her for pulmonary hypertension either by noninvasive
testing such as an echocardiogram or by right-sided heart
catheterization.
2. Ventricular septal defect
- Hemodynamic effects. The size of the defect determines the
degree of disability. A small lesion is hemodynamically insignificant
and is well tolerated. With a large defect with significant left-to-right
shunting, the initial abnormality would be left ventricular hypertrophy
to compensate for the decrease in forward flow followed by the
development of pulmonary hypertension caused by the increased
pressures delivered to the pulmonary vasculature and, finally,
biventricular hypertrophy with the right side pumping against a
significant afterload.
- Effect of pregnancy. The impact of pregnancy will depend on
the hemody namic abnormalities of the individual patient. Without
pulmonary hyper tension, the decrease in systemic vascular resistance caused by pregnancy may be beneficial, causing an increase in forward flow. However, the in crease in blood volume may lead to congestive heart failure in the patient with long-standing left ventricular hypertrophy. When there is preexisting pulmonary hypertension, Eisenmenger's syndrome may develop, a diagno sis that carries a risk of maternal morbidity of 50%. The patient with an uncomplicated repaired ventricular septal defect (VSD) is not at risk
during pregnancy.
- Management during pregnancy. In the absence of pulmonary
hypertension, there are no special requirements during pregnancy
except for bacterial endocarditis prophylaxis. With pulmonary
hypertension, the management should be as for any patient at risk for
Eisenmenger's syndrome.
3. Coarctation of the aorta is frequently associated with
other cardiovascular abnormalities such as bicuspid aortic valve and
cerebral berry aneurysms.
- Hemodynamic effects. Systolic hypertension is common
secondary to the obstruction to outflow, and there is compensatory left
ventricular hyper trophy.
- Effect of pregnancy. With uncomplicated coarctation of the aorta,
preg nancy is usually well tolerated. A minority of cases will be
complicated by congestive heart failure secondary to long-standing
left ventricular hypertrophy and dysfunction. There may be an
increased risk for aortic dissection during pregnancy secondary to the
effect of maternal hormones on the blood vessel wall architecture.
- Fetal effects. Fetal growth may be affected by a relative decrease in
blood flow to the maternal lower body, including the placenta. The
risk for congen ital heart disease in offspring is approximately 20%.
- Management during pregnancy. Hypertension should be
controlled to de crease the risk for aortic dissection and rupture.
Bacterial endocarditis prophylaxis is recommended.
4. Tetralogy of Fallot describes a syndrome of pulmonary
stenosis, right ventric ular hypertrophy, and large ventricular septal
defect with an overriding aorta. This is the most common cyanotic
lesion complicating pregnancy. The vast majority of pregnant women
will have already had full or partial surgical repair, because the
disease is otherwise usually fatal in childhood or early adulthood.
- Hemodynamic effects. There is right outflow obstruction with
resultant right-to-left shunting. This delivers blood with decreased
oxygen satura tion to the systemic circulation. Right ventricular
hypertrophy will develop as a result of the right outflow obstruction.
- Effect of pregnancy. Pregnancy is poorly tolerated in patients who
have not had surgical repair, because the decrease in systemic vascular
resis tance will cause an increase in right-to-left shunting with further
desatura- tion of blood flowing to the systemic circulation. Patients
believed to have an especially poor prognosis in pregnancy are those
with a baseline hematocrit greater than 60%, arterial oxygen saturation
of less than 80%, a history of syncopal episodes, and significant right
ventricular hypertension. Patients with a full surgical repair before
pregnancy are not at increased risk during pregnancy. Patients with
palliative (partial) repairs such as the Blalock- Taussig (anastomosis
of the subclavian artery to the right pulmonary artery), Potts
(anastomosis of the descending aorta to the left pulmonary artery), or
Waterston-Cooley (anastomosis of the ascending aorta to the right
pulmonary artery) may be minimally symptomatic before pregnancy
and yet may be at risk for decompensation during pregnancy.
Therefore, it is important to evaluate functional status by the
parameters just men tioned.
- Fetal effects. The fetus is at risk for growth retardation as a result
of poor oxygen delivery. The risk for congenital heart disease in
offspring is approximately 15 to 20%.
- Management during pregnancy. It is essential to avoid
hypovolemia so as not to further obstruct outflow and increase rightto-
left shunting and to supplement oxygen as necessary.
5. Aortic stenosis may be due to congenital or acquired heart
disease. The most common congenital lesion is a bicuspid valve, and
there frequently are other associated cardiovascular anomalies. The
lesion may not be stenotic at birth but will become progressively
stenotic with aging.
- Hemodynamic effects. When the valve reaches a critical
narrowing in area of less than 1 cm2, there is obstruction to left
ventricular outflow with development of left ventricular hypertrophy.
This, in turn, may result in a fixed stroke volume and ischemia as a
result of poor perfusion of the coronary blood vessels. With additional
stress, the patient may decompen sate, with development of left
ventricular failure.
- Effect of pregnancy. Pregnancy is poorly tolerated in the patient
with critical aortic stenosis. The patient has a fixed stroke volume and
is only able to increase cardiac output to meet the increased demands
of pregnancy by increasing heart rate. An increase in heart rate will
~ 166 ~
relatively decrease the diastolic portion of the cardiac cycle, and this
will result in decreased time for coronary perfusion and ventricular
filling. The risk of maternal mortality with critical aortic stenosis is
approximately 15%; therefore, it is important to discuss and offer
termi nation of pregnancy with severe degrees of disease.
- Fetal effects. There is an increase in perinatal mortality primarily
related to maternal complications. The risk for congenital heart
disease in off spring is approximately 20%.
- Management during pregnancy. In a patient with critical aortic
stenosis, strict limitation of activity is essential to minimize the need
for cardiac output augmentation during pregnancy. It is very important
to avoid situa tions that will further impede venous return such as
hypovolemia. In addition, use of support hose may help to maintain
venous return. Left- sided heart failure should be treated as in the
nonpregnant patient. Bacte rial endocarditis prophylaxis is
recommended. In patients who have had a valve replaced, if the valve
is mechanical, anticoagulation is required. Because warfarin is
contraindicated during the first and third trimesters of pregnancy, the
patient is normally maintained on therapeutic levels of heparin for the
duration of pregnancy.
6. Pulmonary stenosis. Unlike aortic stenosis, this lesion is not
usually progres sive.
- Hemodynamic effects. Mild degrees of pulmonic stenosis usually
cause no symptoms or hemodynamic compromise. With severe
stenosis there will be obstruction to right ventricular outflow, causing
the development of right ventricular hypertrophy.
- Effect of pregnancy. Most patients with pulmonic stenosis tolerate
preg nancy well. However, the patient with severe stenosis may be
unable to meet the demands for augmented cardiac output and may not
tolerate the volume expansion of pregnancy, leading to congestive
heart failure.
- Fetal effects. Congenital cardiac lesions are seen in approximately
20% of offspring.
- Management during pregnancy. Hypervolemia and hypovolemia
should be avoided. Right-sided heart failure should be treated as in the
nonpregnant patient. If the patient fails medical therapy, a surgical
valvotomy may be performed safely during pregnancy. Bacterial
endocarditis prophylaxis is recommended.


119. Newborn care.

Postnatal care
CARE OF INFANT
Post delivery
1. Apgar score (see Neonatal resuscitation).
2. Keep baby warm and dry.
3. Encourage skin-to-skin contact.
4. Check birthweight, body temperature and head circumference within 1 h.
5. Encourage initiation of breastfeeding within 1 h.
6. Offer IM vitamin K (orally if declined).
7. Ensure passing urine, and meconium passed within first 24 h.

Within 72 hours
Full neonatal examination (often completed within 48 hours):
1. Colour, breathing, behaviour, activity, posture, tone.
2. Head circumference. Check fontanelles, palate, nose, ears, symmetry of head and facial
features, assess eyes (red reflex).
3. Limbs: proportions, symmetry, no. of digits, congenital dislocation of the hip.
4. CVS: HR, murmurs, arrythmias.
5. Chest: auscultation, symmetry, signs of respiratory distress, respiratory rate.
6. Abdomen: assess for organomegaly, check umbilical cord insertion site.
7. Genitalia: exclude undescended testes in males.
8. Anus: exclude imperforate anus.
9. Spine: exclude spina bifida.
10. Note any birthmarks.

Assessment at 30 Seconds of Life. Apnea, gasping respirations,
or heart rate < 100 bpm beyond 30 seconds after delivery
should prompt administration of positive-pressure ventilation
with room air. Assisted ventilation rates of 30 to
60 breaths per minute are commonly employed, and the percent
of oxygen saturation is monitored by pulse oximetry. At
this point, supplemental oxygen can be given in graduated
increasing percentages to maintain oxygen saturation (Spo2)
values within a normal range (Vento, 2011). Adequate ventilation
is indicated by improved heart rate.

After the first hour of life, newborns should receive eye care, vitamin K, and recommended immunizations (birth dose of OPV and Hepatitis B vaccine). They should be assessed for birth weight, gestational age, congenital defects and signs of newborn illness. Special care should be provided for sick newborns, those who are preterm and/or low birth weight, and those who are exposed or infected by HIV or have congenital syphilis.


120. Perineal dissection. Indications. Management after delivery.






  


121. Management of breech delivery.












  
122. Retained parts of placenta (causes, clinic, management).






















123. Essential hypertension and pregnancy.

Chronic hypertension (with or without renal
disease) existing prior to pregnancy can predispose to
the later development of superimposed pre-eclampsia.
Even in the absence of superimposed pre-eclampsia,
chronic hypertension is associated with increased
maternal and fetal morbidity and pregnancies
complicated by chronic hypertension should therefore
be regarded as high risk.

In mild cases (

150/100 mmHg) there is no

immediate indication to treat; however, the pregnancy
should be monitored carefully to detect rising blood
pressure or features of pre-eclampsia, as well as FGR
by serial ultrasound scans. Women who are receiving
antihypertensive medication before pregnancy are
often able to discontinue this for the fi rst part of
pregnancy because of the physiological fall in blood
pressure at this time. Some antihypertensives, such as
angiotensin-converting enzyme inhibitors, should be
discontinued because of the fetal risk.
If the blood pressure is consistently noted to
be

150/100 mmHg, antihypertensive medication

will need to be introduced or recommenced. This
is to reduce the risk of severe hypertension and the
attendant risks of intracerebral haemorrhage, although
treatment does not prevent placental abruption or
superimposed pre-eclampsia, nor infl uence perinatal
outcome. Preferred antihypertensive agents include
methyldopa (centrally acting agent) – which is
generally well tolerated, especially if women are
forewarned about the common transient side effects of
lethargy and postural hypotension – labetolol (alphaand
beta-blocker), and nifedipine (calcium-channel
blocker). The aim of antihypertensive medication is to
maintain the blood pressure below 160 mmHg systolic
and 100–110 mmHg diastolic.
The obstetric management of pre-existing
hypertension involves close monitoring for the
development of superimposed pre-eclampsia, which
may present with elevated blood pressure, new-onset
or worsening proteinuria, as well as the development
of FGR. Each case must be individually assessed,
but early delivery is rarely indicated unless preeclampsia
develops or the blood pressure is very
diffi cult to control. In general, it is reasonable to
await spontaneous labour or attempt vaginal delivery
by induction of labour (at around 38 weeks), ensuring
the maternal blood pressure is well controlled.
Post-natally, the maternal blood pressure will often
decrease, but careful observation is required in
the fi rst 48 hours because blood pressure tends to
increase again on the third or fourth postpartum
day. Breastfeeding is encouraged and although some
antihypertensive medication may enter the breast
milk, the standard antihypertensive medications are
not contraindicated in breastfeeding mothers.


124. Prenatal education classes.

A series of classes, either online or in person,
provided for groups of pregnant women and
their partner or support person.

What types of prenatal education
are out there?
• Generic
• Specific to the stage
of pregnancy
• Refresher
• Programs for specific
groups
– Adolescents / Young
– Cultural groups
– Multiple pregnancy
– Diverse family structures
• Online
• Blended
• Drop-in
• One-to-one
• Other
– Transition to parenting
– Centering pregnancy
– Bereaved parents

Is prenatal education effective?
• Effectiveness in increasing the initiation of
breastfeeding.
• Effectiveness in improving specific health
behaviours such as hygiene practices to
reduce toxoplasmosis and follow-up sickle
cell screening.
• Research linking prenatal education to other
health behaviours has been inconclusive due
to selection bias or limited evidence.

What should be taught?
Organized in six main topics, with sub-topics:
– Prenatal health
– Physical and emotional preparation for childbirth
– Interventions to support, comfort and provide pain
management during labour and birth
– Physical, emotional and social needs of the new
family
– Breastfeeding
– The newborn

125. Maternity leave.

Maternity leave is a temporary period of absence from employment granted to expectant or new mothers during the months immediately before and after childbirth. These policies are generally aimed at supporting the mother's full recovery from childbirth and facilitating a stronger mother-child bond.

126. Course and management of second stage of labor.

The second stage
This lasts from full dilatation of the cervix to delivery.
Descent, flexion and rotation are completed and followed
by extension as the head delivers.
The passive stage lasts from full dilatation until the head
reaches the pelvic floor and the woman experiences the
desire to push. Rotation and flexion are commonly
completed. This stage may last a few minutes, but can
be much longer.
The active stage is when the mother is pushing. The
pressure of the head on the pelvic floor produces an
irresistible desire to bear down, although epidural analgesia
may prevent this. The woman gets in the most
comfortable position for her, but not supine, and pushes
with contractions. The fetus is delivered, on average,
after 40 minutes (nulliparous) or 20 minutes (multiparous).
This stage can be much quicker, but if it takes
>1 h spontaneous delivery becomes decreasingly likely.




Clinical Management of the Second Stage
As in the first stage, certain steps should be taken in the clinical
management of the second stage of labor.
Maternal Position. With the exception of avoiding the supine
position, the mother may assume any comfortable position for
effective bearing down. If the birth is to occur in another room,
primiparous patients should be moved at or before the beginning of crowning. Multiparous patients should be brought to the delivery room at the time of complete cervical dilation.
Bearing Down. With each contraction, the mother should be
encouraged to hold her breath and bear down with expulsive efforts. This is particularly important for patients with regional anesthesia because their reflex sensations may be impaired.
Fetal Monitoring. During the second stage, the fetal heart rate
should be monitored continuously or evaluated every 5 minutes in
patients with obstetric risk factors. Fetal heart rate decelerations (head compression or cord compression) with recovery following the uterine contraction may normally occur during this stage.
Vaginal Examination. Progress should be recorded
approximately every 30 minutes during the second stage. Particular attention should be paid to the descent and flexion of the presenting part, the extent of internal rotation, and the development of molding or caput.

127. Dropsy of pregnancy. Clinic, diagnostic, management.
Dropsy pregnant (swelling pregnant) is one of the forms of toxicity second half of pregnancy, characterized by swelling in the absence of protein in the urine and normal blood pressure. Usually occurs after 28-30 weeks of pregnancy, often multiple. Edema is due to violation of water-salt metabolism and blood circulation in the system of capillaries and precapillaries in the result of changes in neuroendocrine regulation. In the development of dropsy pregnant plays the role of a previous state of the body (metabolism with a tendency to be overweight, liver disease and other).

Clinic
Clinical presentation and course. The disease develops more often gradually. Before the appearance of visible swelling may occur the so-called signal symptoms: excessive weight gain during the week (more 250-400 grams), symptoms of the "ring" (the ring on your finger becomes logopedija), "tight shoes" (worn shoes becomes close). If timely measures are not taken, visible swelling. There are 4 the prevalence of edema: 1) only swelling in the feet and lower legs; 2) swelling of the lower extremities, the lower part of the abdomen and lumbar-sacral region (if the woman is); 3) in addition to these, edema on the hands, pastos person; 4) General swelling. The skin becomes glossy look, saving, however, normal color (no pallor observed in renal edema, cyanosis, as edema associated with heart disorder). Even when pronounced edema of cardiac activity, liver, kidneys is not observed. There are no also accumulation of fluid in the cavity (pleural and abdominal). In a period of growth swelling observed decrease of urine output (negative diuresis), reducing its proportion. The General condition of the pregnant remains satisfactory.
Forecast at a dropsy pregnant is usually favorable, timely treatment gives good results, pregnancy born at the end and ends with childbirth. After delivery dropsy pregnant disappears. In rare cases, if the prevention and treatment has not been organised properly, the disease can move rapidly in nephropathy pregnant and even eclampsia.

Management and Prevent
When the signal symptoms dropsy pregnant midwife should refer the pregnant woman to the district hospital for consultation. At diagnosis dropsy pregnant during this period it is recommended diet with restriction of salt (not more than 2 g / day), reduce the amount of fluid (not more than 800 - 1000 ml per day). A careful monitoring (every week, sometimes more often!) weight, blood pressure, repeated analyses of urine. Action taken in time can prevent development of toxemia.
With the development of explicit edema treatment should be carried out in the hospital. Only in exceptional cases, if there is confidence that the patient will perform all assignments and homes can provide good care, treatment can be performed at home under surveillance antenatal clinic. Prescribe diuretics - gipotiazid (25 mg 2 times in the morning at four-hour intervals) 3 consecutive days, for the night sedatives: motherwort tincture at the rate of 10 g to 200 g of water on 1 table, HP, papaverine 0.02 g, better in candles (for 1 suppository 2 times a day). The woman should stay in bed (better defined the diuretic effect). Once a week, spend a day of fasting (fluid restriction to 800 ml and salt to 2 g per day) and after poluraspredelenia (without the first liquid dish). Prescribe vitamins (vitamin C, vitamins of group b). If within 3-4 days of improvement does not occur, then treated as if nephropathy pregnant.
Prevention. Careful monitoring and active patronage of pregnant women, monitor their observance of hygiene, especially diet. Cm. also Pregnancy.

Diagnosis and Tests
To check for edema that is not obvious, you can gently press your thumb over the foot, ankle or leg with slow, steady pressure.  If edema is present, an indentation will show on the skin.  A professional evaluation to determine the cause of leg swelling is needed.  If both legs are swollen, your doctor will inquire about other symptoms and perform a physical examination.  A urine test will show whether you are losing protein from the kidneys.  Blood tests, a chest X-ray and an electrocardiogram (ECG) may be ordered.

128. Aseptic and antiseptic in obstetrical practice.

Proper client preparation with antiseptics before an obstetric procedure, such as a cesarean section or uterine evacuation, involves applying
an antiseptic solution to the client’s skin, vagina, cervix, or perineum
to destroy or prevent the growth of microorganisms. Most
surgical-site infections result from contamination during surgery—
not, as many people believe, because clients do not keep the wound
clean after surgery. Frequently, infections are caused by bacteria
from the client’s skin or tissues. Therefore, proper client prep before a procedure is critical.

Common antiseptics used for client prep:
• An iodophor (e.g., Betadine)
• 4% chlorhexidine gluconate (e.g., Hibiclens)
• Chlorhexidine gluconate with cetrimide (e.g., Savlon)
• 1–3% iodine, followed by 60–90% alcohol (ethyl or isopropyl). Note:
Alcohol and alcohol-based antiseptics should be used on the skin
only; do not use them to prepare the vagina, cervix, or perineum.

Provide the following immunization to any woman who
had an unhygienic delivery or an unsafe termination of
pregnancy:
• If she has already been immunized, give a booster injection of tetanus
toxoid 0.5 mL IM.
• If she has not been immunized, give antitetanus serum 1,500 units IM
immediately, and tell her to return in four weeks for a booster injection
of tetanus toxoid 0.5 mL IM.

When the use of prophylactic antibiotics is indicated for
emergency obstetric care:
• Use broad-spectrum antibiotics (e.g., ampicillin, cephalosporins, or
combination antibiotics) that are effective against the microorganisms
most likely to cause infections.
• Whenever possible, give prophylactic antibiotics before or during the
procedure, not afterward. (During cesarean sections, administer broadspectrum
antibiotics immediately after clamping the cord.)
• Give only a single dose of antibiotics, unless surgery is prolonged (more
than 6 hours) or blood loss is excessive (more than 1.5 L).

Aseptic Technique
“Aseptic technique” refers to the practices performed just before or
during a clinical or surgical procedure to reduce the client’s risk of
infection by reducing the likelihood that microorganisms will enter
areas of the body where they can cause infection.
Aseptic technique includes:
• Surgical scrub
• Using physical barriers (such as gloves and other surgical attire,
surgical drapes, and pads)
• Client prep
• Establishing and maintaining a sterile field
• Good surgical technique
• Appropriate use of prophylactic antibiotics
• Creating a safer surgical/procedure area

129. Management of acute anemia in obstetrical practice.





130. Mechanism of delivery on flat pelvis.
Check question 114



131. Methods of estimating fetal weight before labor.
Tactile assessment

a) Clinical Methods: In clinical methods tactile assessment
of foetal size, clinical risk factor estimation, Maternal
self estimated foetal weight and Prediction equations of
birth weight are included.
b) Imaging Methods: This includes ultrasonography and
magnetic resonance imaging. Some investigators
consider sonographic estimates to be superior to clinical
estimates others confer similar level of accuracy.
Several studies indicate that physician conducted
physical examination of pregnant women and estimated
foetal weight are superior to ultrasonic foetal
measurement (3-7,12-46).Williams textbook concludes
that estimation of foetal weight from ultrasonic
measurements is not proven to be reliable(47).It even
carries a risk of sonologically induced chromosomal
anomalies.


Dare et al used this technique by multiplying the abdominal
girth (cm) with symphysiofundal height (cm) and calculated the
estimated foetal weight in grams (21).However, this is less
accurate for obese than non obese and carries a significant intra
observer variation. The inherent growth potential of the baby and
nutritional status of the mother are concurrently measured. The
resultant estimate is closest to the actual birth weight as pointed
by several prospective studies (1, 26, 27, 29, 34).
Clinical risk Factor
This method involves quantitative assessment of clinical risk
factors and has been shown to be valuable in predicting foetal
weight. In case of foetal macrosomia ,the presence of risk factors
,such as maternal diabetes mellitus ,prolonged pregnancy, obesity
,pregnancy weight gain of >20 kg, maternal age >35 years,
maternal height> 5ft 3 inches, multiparity, male foetal sex and
white race should be added. In low estimated birth weight
socioeconomic status, constitutionally small mother, poor
maternal weight gain, foetal infections, congenital
malformations, chromosomal abnormality, teratogenic exposure,
maternal anaemia, Anti phospholipid Antibody syndrome and
other medical disorders complicating pregnancy should be
mentioned.
Maternal Self estimation
In literate society maternal self estimation of foetal birth
weight in multiparous women show comparable accuracy to
clinical palpation in some studies for predicting abnormally large
foetus (24,29).



Birth weight Prediction equations
Various calculations and formulae based on measuring
uterine fundal height above symphysis pubis have been
developed. Ojwang et al used the product of symphysiofundal
height and abdominal girth measurement at various levels in
centimetres above symphysis pubis in obtaining a fairly
acceptable predictive value but with considerable variation from
the mean(20).Dare et al simplified and used the product of
symphysiofundal height(Mc Donald’s measurement) and
abdominal girth at the level of umbilicus measured in centimetres
and result expressed in grams to estimate foetal weight in uteru at
term ,and the estimation correlated well with birth weight (21).
Johnson’s formula for estimation of foetal weight in vertex
presentation is as follows
 Foetal weight (grams) = (Mc Donald’s measurement of
symphysiofundal height in cm –X) x 155 where X = 13, when
presenting part was not engaged, X = 12 when presenting part is
at 0 station and X = 11 when presenting part was at +1 station. If
a patient weighs more than 91 kg, 1cm is subtracted from the
fundal height.
 Dawn’s formula states that weight (grams) = longitudinal
diameter of the uterus x transverse diameter of the uterus x
1.44/2 .Measurements are made with pelvimeter. Double
abdominal wall thickness was also measured pelvimeter. If
Double abdominal wall thickness was more than 3 cm, the excess
was deducted from the longitudinal diameter

obstetric ultrasonography

MRI

132. Blood transfusion in obstetric practice.








133. Ruptures of cervix (causes, diagnostic, management).








134. Medical indications for artificial abortion.

A The continuance of the pregnancy would involve risk to
the life of the pregnant woman greater than if the pregnancy
were terminated
B The termination is necessary to prevent grave permanent
injury to the physical or mental health of the pregnant
woman
C The pregnancy has not exceeded its 24th week and that
the continuance of the pregnancy would involve risk,
greater than if the pregnancy were terminated, of injury to
the physical or mental health of the pregnant woman
D The pregnancy has not exceeded its 24th week and that
the continuance of the pregnancy would involve risk,
greater than if the pregnancy were terminated, of injury to
the physical or mental health of any existing child(ren) of
the family of the pregnant woman
E There is a substantial risk that if the child were born it
would suffer from such physical or mental abnormalities
as to be seriously handicapped

 Maternal




Fetal




135. Cephalohematoma.







136. Craniotomy. Indications. Conditions. Technique.

Definition
It is an operation to make a perforation on the fetal head , to evacuate thecontent followed by extraction of the fetus.

Indications
*      Cephalic presentation producing obstructed labour with dead fetus
*      Hydrocephalus  even in a living fetus – this is applicable for bith forecoming and aftercoming head .
*      Interlocking head of twins
Condition to be full filled
®    The cervix must be fully dilated
®    Baby must be dead
Contraindication
®    The operation should not be done when the pelvis is severly contracted. So as to shortened the true conjugate to less than 7.5cm (3``). In such condition the baby cannot be delivered as the bimastoid diameter 7.5cm which cannot be compressed.
®    Rupture of the uterus were laprotomy is essential
Procedure
Step1
Two fingers are introduced in to the vagina and the finger tips are to be planned on proposed site of perforation. However when the suture line cannot be defined because of big caput , the perforation should be done through the dependent part.
Site of preparation
Vertex:- on the parietal bone either side of the sagittal sutures is avoided to prevent collapse of the bone thereby preventing escape of the brain matter
Face :- through the orbit or hard plate
Brow :-  through the frontal bone
Step 2
The Oldham’s perforator , with the blades closed , is introduced under the palmaraspect of the fingers protecting the anterior vaginal wall and the adjacent bladder until the tip reaches the proposed site of perforation.
Step 3 :- By rotating movements the skull is perforated . during this step, an assistant is asked to steady the head per abdomen in a manner of first pelvic grip. After the skull is perforated , the instrument is thrust up to the shoulder and the handles approximated ,so as to allow separation of the sharp blades for about 2.5 cm .  
            The blades are again apposed by separating the handles. The instruments is brought out keeping the tip of the blades still inside the cranium the instruments is rotated at right angle and then again threst inup to the shoulders. The handles are once more to be compressed of as to separate the blades for about 2.5cm. The perforator area now looks like a cross. The instruments with the blades closed is then thrust in beyond the guard to churn the brain matter. The instruments with the blades closed , is brought out under the guidance of the two fingers still placed inside the vagina.
Alternative to Oldham’s perforator , similar procedure could be performed using a sharp pointed Mayo’s  scissors.
Step 4 :- With the fingers brain matter is evaluated. The idea is to make the skull collapsed as much as possible.
Step 5 :-when the skull is found sufficiently compressed, the extraction of the fetus is achieved either by using cranioclast or by two Gaint Vulsella are used to hold the incised skull and scalp margins.
Step 6 :- the traction is now excreted in the same direction is like that mentioned in forceps operations.
Step 7 :- after the delivery of the placenta, the uterovaginal canal must be explored as a routine for evidence of rupture uterus or any tear.
Inj. Methergin 0.2mg is to be given intravenously with the delivery of the anterior shoulder. The rest of the delivery is completed as in normal delivery.
Forceps Vs craniotomy in a dead fetus
If the delivery of the uncompressed head can be accomplished with out much force with consequent injuries to the mother, forceps delivery is preferred. But if it is found difficult and damaging to the mother, craniotomy is safer.


137. Signs of preterm infant.











138. Structure of maternity hospital.

Minsk health care institution “City clinical maternity hospital №2» provides highly qualified obstetric-gynecologic help for women and newborns of Minsk. Our maternity hospital is a perinatal center of the third level, a premature delivery management center.
The institution has the following structure:
·         an obstetric-gynecologic in-patient department where both term and premature deliveries take place, newborns are treated and cared for, and gynecologic surgeries are performed, including laparoscopic surgeries. About 6 000 deliveries take place in the maternity hospital during one year, and 125 thousands children were born at the maternity hospital over more than 30 years;
·         an interdistrict center of perinatal ultrasound diagnostics where screening ultrasound examinations during the pregnancy are performed. More than 25000 pregnant women are examined in the center during one year. About 9000 gynecologic examinations, up to 4000 thyroid gland, mammary glands, abdominal cavity organs, man’s urogenital system examinations are performed in the ultrasound diagnostics department of the maternity hospital. The examinations are performed with the help of the advanced equipment by qualified specialists;
·         a family planning city center where infertile married couples, women with recurrent pregnancy loss undergo therapy, and а preparation for the delivery with the partner is performed. More than 1000 couples have become happy parents over the years of center existence.Since 2004 a full course of infertility treatment has been held, including additional reproductive techniques (IVF and others). About 400 couples are trained at partner delivery courses.

139. Neonatal injuries associated with labor.

Common Birth-Related Traumas
Generally, the most common neonatal injuries affect a baby’s head, neck, and shoulders, although they can cause damage to any other part of the body. These areas of the body are more likely to be injured because most babies are born in a head-first position. According to the Packard Children’s Hospital, the most common traumatic injuries include:

Caput Succedaneum
Caput succedaneum is a condition marked by scalp swelling, typically during or shortly after birth. It is usually caused by pressure from the mother’s uterus or vaginal wall during delivery. Bruising of the scalp is more likely to happen during a long and difficult labor, especially in situations when the amniotic sac has broken and the baby’s head is unprotected while passing through the birth canal.

Caput succedaneum can also be caused by the use of vacuum extraction devices during a protracted delivery.

Cephalohematoma
Cephalohematoma is an accumulation of blood below the baby’s periosteum, the protective membrane that covers an infant’s skull. Cephalohematoma shows up as lumps on a baby’s head, usually several hours after delivery. The lumps feel soft and may grow larger during the baby’s first hours postpartum.

Most cephalohematomas do not require medical attention and disappear within a few weeks or months as the body reabsorbs the blood. However, some cephalohematomas may cause jaundice if they are too large and too many red blood cells break down.

Bruising and Broken Bones
Bruising may occur on a baby’s face, head, and/or other body parts due to the physical stresses of the passage through the birth canal or contact with bones and tissue in the mother’s pelvis. The use of forceps during delivery may also leave forceps marks on a newborn’s head or face, especially when doctors use too much force. In addition, vacuum extraction may cause lacerations or bruising on a baby’s scalp.

Similar to bruising, broken bones can occur with improper use of birth-assisting tools or when an infant is tugged too forcefully. In extremely rare instances, a physician or someone on the medical staff may drop a newborn.

Subconjunctival Hemorrhage
Subconjunctival hemorrhage is bleeding that occurs when small blood vessels in the baby’s eyes break. It may be present in one or both of the infant’s eyes and appears as a bright red band surrounding the iris. Subconjunctival hemorrhages do not cause permanent damage to the eyes. The red area vanishes within a matter of days as the body reabsorbs the blood.

Bell’s Palsy
Bells’ palsy occurs when a baby’s facial nerve is damaged during labor or birth. In most cases, nerve damage is caused by pressure on the infant’s face during the passage through the birth canal.However, facial paralysis can be also caused by doctors that use forceps during delivery.

Nerve damage is most noticeable when babies cry. The facial muscles on the side where the nerve was injured can’t move, and the eye on that side remains open.

Bell’s palsy eventually improves without treatment if the nerve is only bruised. If the baby’s facial nerve is torn, surgery may be needed to restore muscular function on the affected area.

Brachial Plexus Injury
A brachial plexus injury is the result of an injury to a baby’s brachial plexus. This is a network of nerves that connects the spinal cord to the baby’s arms and hands. Brachial palsy is a common occurrence in difficult births, especially if a baby’s shoulder gets stuck in the birth canal and a doctor tugs hard on one arm to help extract the newborn.

The most common sign of brachial palsy is when a baby can’t flex or rotate the affected arm. The severity of the injury depends on how badly damaged the nerves are. If the nerves are only bruised or stretched, the injury heals over a period of weeks or months and arm movement is restored with the aid of physical therapy.

More serious injuries, in which the nerves are torn, often result in permanent nerve damage.

Oxygen Deprivation
Oxygen deprivation, or anoxia, before or during birth can cause serious health problems to a newborn. This type of birth of trauma can occur if the placenta separates prematurely or if the umbilical cord becomes entangled around the baby’s neck and reduces oxygen flow to the brain.

Inadequate oxygen supply often causes damage to a baby’s cerebellum, the part of the brain that controls the body motor functions. This results in the onset of cerebral palsy (CP), a group of neuromuscular disabilities that affect a child’s ability to control movement, posture, and muscle tone.

Oxygen deprivation can also occur if a baby doesn’t start breathing independently after birth. Delays in breathing that last for 3 minutes or more are a high risk factor of serious brain damage. This category of birth injury destroys brain cells within a matter of minutes and causes seizures, coma, and, if a baby is not placed in life support in time, death.

Oxygen deprivation causes permanent disabilities like cerebral palsy, and is also a major cause of hearing impairment, partial or total blindness, learning disabilities, and other complications.

Hypoxia is a slightly less severe form of oxygen-related birth trauma. Unlike anoxia, which is used to describe total oxygen deprivation, hypoxia refers to low levels of oxygen in a baby’s circulatory system.

Fractures
Fractures are the most common injuries associated with birth trauma. Fractures generally affect a baby’s clavicle (collarbone) and are frequently caused by shoulder dystocia or during breech deliveries. This type of injury prevents a baby from moving the arm on the affected side. If the infant feels pain as a result of the fracture, a splint or soft bandage is needed to prevent jostling of the arm until the injury heals.

Most birth traumas are conditions that usually heal on their own without any medical treatment. Babies often recover with few or no complications, although individual outcomes depend on a wide range of factors, such as the severity and cause of the injuries.

In many instances, birth trauma can be avoided if doctors recognize and foresee medical risk factors. Proactive measures, such as monitoring the mother’s health or using ultrasound images to check the fetus’ position in the weeks and days before labor, often prevent help birth trauma and injuries.

140. Amniotic fluid embolism.







141. Placenta accreta and placenta percreta.
The placenta normally attaches to the uterine wall, however there is a condition that occurs where the placenta attaches itself too deeply into the wall of the uterus.

This condition is known as placenta accreta, placenta increta, or placenta percreta depending on the severity and deepness of the placenta attachment. Approximately 1 in 2,500 pregnancies experience placenta accreta, increta or percreta.

What is the difference between accreta, increta or percreta?
The difference between placenta accreta, increta or percreta is determined by the severity of the attachment of the placenta to the uterine wall.

Placenta Accreta occurs when the placenta attaches too deep in the uterine wall but it does not penetrate the uterine muscle. Placenta accreta is the most common accounting for approximately 75% of all cases. Placenta Increta occurs when the placenta attaches even deeper into the uterine wall and does penetrate into the uterine muscle. Placenta increta accounts for approximately 15% of all cases. Placenta Percreta occurs when the placenta penetrates through the entire uterine wall and attaches to another organ such as the bladder. Placenta percreta is the least common of the three conditions accounting for approximately 5% of all cases.

What causes placenta accreta?
The specific cause of placenta accreta is unknown, but it can be related to placenta previa and previous cesarean deliveries. Placenta accreta is present in 5% to 10% of women with placenta previa.
A cesarean delivery increases the possibility of a future placenta accreta, and the more cesareans, the greater the increase. Multiple cesareans were present in over 60% of placenta accreta cases.
What are the risks of placenta accreta to the baby?
Premature delivery and subsequent complications are the primary concerns for the baby. Bleeding during the third trimester may be a warning sign that placenta accreta exists, and when placenta accreta occurs it commonly results in a premature delivery.
Your healthcare provider will examine your condition and use medicationbed rest and whatever else necessary to help continue the pregnancy towards full term.
What are the risks of placenta accreta to the mother?
The placenta usually has difficulty separating from the uterine wall. The primary concern for the mother is hemorrhaging during manual attempts to detach the placenta. Severe hemorrhaging can be life threatening.
Other concerns involve damage to the uterus or other organs (percreta) during removal of the placenta. Hysterectomy is a common therapeutic intervention, but the results involve the loss of the uterus and the ability to conceive.
What is the treatment for placenta accreta?
There is nothing a woman can do to prevent placenta accreta, and there is little that can be done for treatment once placenta accreta has been diagnosed. If you have been diagnosed with placenta accreta your healthcare provider will monitor your pregnancy with the intent of scheduling a delivery and using a surgery that may spare the uterus.
It is particularly important to discuss this surgery with your doctor if you desire to have additional children.
Unfortunately, placenta accreta may be severe enough that a hysterectomy may be needed. Again, it is important to discuss surgical options with your healthcare provider.

142. Congenital anomalies.
Definition
Congenital anomalies are also known as birth defects, congenital disorders or congenital malformations. Congenital anomalies can be defined as structural or functional anomalies (e.g. metabolic disorders) that occur during intrauterine life and can be identified prenatally, at birth or later in life.
Causes and risk factors
Although approximately 50% of all congenital anomalies cannot be linked to a specific cause, there are some known causes or risk factors.
Socioeconomic and demographic factors
Although low income may be an indirect determinant, congenital anomalies are more frequent among resource-constrained families and countries. It is estimated that about 94% of severe congenital anomalies occur in low- and middle-income countries, where women often lack access to sufficient, nutritious food and may have increased exposure to agents or factors such as infection and alcohol that induce or increase the incidence of abnormal prenatal development. Further, advanced maternal age increases the risk of chromosomal abnormalities, including Down syndrome, while young maternal age increases the risk of some congenital anomalies.
Genetic factors
Consanguinity (when parents are related by blood) increases the prevalence of rare genetic congenital anomalies and nearly doubles the risk for neonatal and childhood death, intellectual disability and other anomalies in first-cousin unions. Some ethnic communities (e.g. Ashkenazi Jews or Finns) have a comparatively high prevalence of rare genetic mutations, leading to a higher risk of congenital anomalies.
Infections
Maternal infections such as syphilis and rubella are a significant cause of congenital anomalies in low- and middle-income countries.
Maternal nutritional status
Iodine deficiency, folate insufficiency, obesity and diabetes mellitus are linked to some congenital anomalies. For example, folate insufficiency increases the risk of having a baby with a neural tube defect. Also, excessive vitamin A intake may affect the normal development of an embryo or fetus.
Environmental factors
Maternal exposure to certain pesticides and other chemicals, as well as certain medications, alcohol, tobacco, psychoactive drugs and radiation during pregnancy, may increase the risk of having a fetus or neonate affected by congenital anomalies. Working or living near, or in, waste sites, smelters or mines may also be a risk factor, especially if the mother is exposed to other environmental risk factors or nutritional deficiencies.
Prevention
Preventive public health measures delivered through health services decrease the frequency of certain congenital anomalies. Primary prevention of congenital anomalies includes:
·         improving the diet of women throughout their reproductive years, ensuring an adequate dietary intake of vitamins and minerals, and particularly folic acid, through daily oral supplements or fortification of staple foods such as wheat or maize flours;
·         ensuring mothers abstain from, or restrict, their intake of harmful substances, particularly alcohol;
·         controlling preconceptional and gestational diabetes, through counselling, weight management, diet and administration of insulin when needed;
·         avoiding environmental exposure to hazardous substances (e.g. heavy metals, pesticides) during pregnancy;
·         ensuring that any exposure of pregnant women to medications or medical radiation (e.g. imaging rays) is justified, based on careful health risk–benefit analysis;
·         improving vaccination coverage, especially against the rubella virus, for children and women. Rubella can be prevented through childhood vaccination. The rubella vaccine can also be given at least 1 month prior to pregnancy to women who have not been vaccinated and do not have a history of rubella in childhood;
·         increasing and strengthening education of health staff and others involved in promoting prevention of congenital anomalies.
Detection
Health care before (preconception) and around the time of conception (peri-conception) includes basic reproductive health practices, as well as medical genetic screening and counselling. Screening can be conducted during the 3 periods listed next.
·         Preconception screening can be useful to identify people at risk for specific disorders or at risk for passing a disorder onto their children. Screening includes obtaining family histories and carrier screening, and is particularly valuable in countries where consanguineous marriage is common.
·         Peri-conception screening: maternal characteristics may increase risk, and screening results should be used to offer appropriate care, according to risk. This may include screening for young or advanced maternal age, as well as screening for use of alcohol, tobacco or other psychoactive drugs. Ultrasound can be used to screen for Down syndrome during the first trimester, and for severe fetal anomalies during the second trimester. Additional tests, and amniocentesis may help in the detection of neural tube defects and chromosomal abnormalities during the first and second trimesters.
·         Neonatal screening includes clinical examination and screening for disorders of the blood, metabolism and hormone production. Screening for deafness and heart defects, as well as early detection of congenital anomalies, can facilitate life-saving treatments and prevent progression towards some physical, intellectual, visual or auditory disabilities. In some countries, babies are routinely screened for abnormalities of the thyroid or adrenal glands before discharge from the maternity unit.
Treatment and care
Many structural congenital anomalies can be corrected with paediatric surgery and early treatment can be administered to children with functional problems such as thalassaemia (inherited recessive blood disorders), sickle cell disorders and congenital hypothyroidism (reduced function of the thyroid)

Note: For specific anomalies
http://www.slideshare.net/doc1811/congenital-malformations


143. Nausea and vomiting at pregnancy. Clinic, diagnostic, management.

















144. Threatened and imminent abortion.









145. Diagnostic of anterpartum asphyxia.





146. Premature rupture of membranes. Causes. Complications. Prevention.

Prelabour rupture of membranes (PROM) at term

DEFINITION Spontaneous rupture of membranes prior to onset of labour at term.

AETIOLOGY Natural physiological mechanisms including Braxton Hicks contractions and
cervical ripening lead to weakening of the membranes.

ASSOCIATIONS/RISK FACTORS None known.

EPIDEMIOLOGY Affects 8% of pregnant women.

HISTORY Sudden gush of fluid loss PV, followed by constant trickle.

EXAMINATION
General: Assess for signs of infection (fever, tachycardia).
Vaginal: Avoid if possible (" risk infection).
Speculum: (If history uncertain) confirm pooling of liquor in vagina, note liquor colour.

PATHOLOGY/PATHOGENESIS NA.

INVESTIGATIONS
Microbiology: Consider HVS/LVS.

MANAGEMENT
Clear liquor and no known GBS
Expectant management for 24 hours (majority ofwomenwill labour). Offer augmentation of
labour after 24 hours (may opt for expectant management for up to 72 hours with 4-hourly
temperature and 24-hourly fetal monitoring). Augment labour with prostaglandin or
oxytocin infusion. Antibiotic cover (benzylpenicillin or clindamycin if penicillin allergic)
dependent on unit protocol.
Meconium or known GBS or pyrexia
Augment labour immediately (antibiotics if known GBS/pyrexia).
Postnatal
Neonatal observation required for at least 12 hours.

COMPLICATIONS Increased risk of ascending infection.

PROGNOSIS Sixty percent of women will labour over the next 24 hours.

147. Threaten rupture of uterus.
Threatening diagnosis of uterine rupture particularly difficult in cases where signs of overdistension of the uterus are mild or absent. In such cases it is necessary to be guided symptom of "filling of the bladder," or the appearance of protrusions above the vagina (a consequence of tissue edema in the bladder), unexpectedly coming asphyxia, the onset of involuntary bearing-down activity with high standing head, etc. However, these symptoms are often absent or are expressed extremely weak.
The appearance of pregnant women who have had previous cesarean section before the onset of labor (or during birth) bleeding from the uterus, sometimes accompanied by pain in the abdomen or in the uterus (in the old scar), should be seen as signals of a possible spread of incipient uterine scar tissue.
In the event of rupture of the uterine scar are not only the morphological change of the tissues, but the germination of the elements of trophoblast in the uterine wall at the former site of the incision.
Behavior of mothers with a typically flowing threatening uterine rupture is very characteristic: it is torn in the bed all the time moaning, begging for help, complaining about "bursting" pain in the abdomen, which is observed both outside and during the fight. Face red, frightened. Tongue and lips dry. Pulse and respiration are increasing dramatically. The body temperature usually rises, due to excessive muscular work of the uterus.
In some cases, a woman in labor at times even lose consciousness. The pressure of the presenting part on the bladder causing more frequent urination. The woman in this state, reflexively straining, which, of course, only accelerates the onset of uterine rupture.
In threatening uterine rupture should immediately stop further overstretching of the uterus, which is partly achieved by moving the pregnant woman to the position on the side opposite to the existing position of the fetus. Assigned injection pantopon, magnesium sulphate and deep inhalation anesthesia in order to complete shutdown of labor for the time necessary to prepare for the operation.
Method of delivery should be carefully and gentle. Significant role in the choice of a treatment is the situation and the conditions in which the doctor works. Those surgical activities that can be easily applied in clinics and hospitals (cervical or corporeal cesarean section) are not always available in a GP practice. Where there are no conditions for the production of C-section, the doctor is forced to resort to the old methods of vaginal delivery — to the punch head with kranioklaziey (when presenting the head) or decapitation, exenteration of the chest, eventeratsii (with transverse or oblique position of the fetus). Said operations should be carried out with great care, without much physical effort. We must always remember that every action may cause grave gap cancer or help to increase the size of an existing injury.
The method of choice for threatening uterine rupture is in uninfected cases and with a live fetus cesarean section and only in exceptional cases (if you can not make a C-section or stillbirth) — plodorazrushayuschie operation.
With cephalic presentation (occipital, frontal, facial or perednegolovnoe) perforation head dvuzubtsami captured by the skin, must be carried out under the control of the mirrors, with subsequent destruction of the brain with a spoon and scooping it out (washout).
When mobile (pressed) to fix her head at the entrance to the pelvis through the abdominal wall should be very careful to avoid further injury.
Must be very careful and overlay diaclast. Extraction of the fetus should be slow and smooth, without the use of excessive force and carried out in accordance with Biomechanism birth. During the traction necessary to monitor the throat, while the edges as needed seasoned finger.      
With the wide shoulder girdle is kleydotomiya, and sometimes — and exenteration of the chest.
At birth in breech made subsequent perforation head.
In threatening uterine rupture in the event of running transverse position fetal cephalic strictly prohibited even with a live fetus and under deep anesthesia. Turn under such conditions usually lead to uterine rupture and new complications.
In threatening uterine rupture, we absolutely are against transporting women from one hospital to another, and we believe it necessary to carefully rodorazreshayuschih her in this situation, at least with plodorazrushayuschih operations. In the absence of conditions for delivery on-site transportation is admissible as an exception mothers after shutdown of labor (the injection of morphine, deep anesthesia, etc.) must accompany the woman in childbirth doctor or midwife.







148. Physical examinations of newborn in the delivery room.

Initial post-delivery examination
A brief screening examination should be conducted checking the face, eyes, mouth, chest, abdomen, spine and limbs to exclude major abnormalities. A strong cry and a widespread pink blush over the face and body are good signs that all is well. Some children may be born with indiscriminate genitalia. In such cases it is important not to guess at the likely gender of the child, but advise that it is uncertain and that further tests will be needed. If you have sufficient clinical experience, an orogastric tube should be passed when the neonate's mother has suffered polyhydramnios. This excludes oesophageal atresia.
The APGAR score
The Apgar score gives a reproducible, quantitative, semi-objective assessment of neonatal condition that is useful for assessing a baby's progress or deterioration immediately after delivery.[2] It is important to document it for medicolegal reasons. It is most useful following complicated births or where there are unanticipated problems with the baby after delivery. It should be checked at delivery and two and five minutes subsequently; these results should be documented in the partogram, maternal and neonatal notes.
The Apgar Scoring System
Assigned score
0
1
2
Colour of baby
Blue, pale
Body pink, extremities blue
Completely pink
Respiratory effort
Absent
Weak cry, hypoventilation
Good, strong cry and adequate breaths

Muscle tone

Limp

Some flexion of extremities

Active motion with extremities well flexed
Reflex irritability (response to plantar stimulation)
No response
Grimace
Cry
Heart rate
Absent
Slow (<100 bpm)
Fast (>100 bpm)
There is an excess of mortality and an increased risk of severe neurological morbidity in infants with total Apgar score <7 at five minutes.[3]
Routine neonatal examination
Known colloquially as 'the baby check', this examination should be carried out by a member of the paediatric team where the baby is still in hospital, or by the GP and primary care team following home births. The National Institute for Health and Care Excellence (NICE)[2] recommends that the aims of the examination should be fully explained to the parent(s) before it is conducted. The findings should be shared with the parent(s) and recorded in the postnatal care plan and the personal child health record. NICE advises that the examination should be carried out within 72 hours of birth and incorporate:
·         A review of parental concerns and the baby's medical history
·         Family, maternal, antenatal and perinatal history
·         Fetal, neonatal and infant history, including any previously plotted birth weight and head circumference
·         Whether the baby has passed meconium and urine (and urinary stream in a boy)
·         Other screening tests as recommended by the UK National Screening Committee should also be carried out or arranged at this time[1] 
The examination is best conducted in a well-lit, warm, private room with the mother in attendance and able to see and help with what is being done.
Suggested schema for screening neonatal examination
First wash your hands thoroughly to reduce the risk of cross-infection. Then:

Listen and observe
·         Assess overall appearance. Note general tone, sleepiness and rousability. Observe general condition, proportions and maturity.
·         Look carefully for evidence of jaundice (preferably in bright, natural light). Note whether there are any birthmarks, rashes or other skin abnormalities.
·         Listen to the baby's cry and note its sound.
·         Weigh the baby and plot this reading on its growth chart.
Perform a systematic 'head to toes' examination
This should be done carefully and in good light to detect abnormalities:
·         Head:
·         Shape, presence of fontanelle and whether normal, sunken or bulging.
·         Measure and record head circumference on the growth chart.
·         Assess facial appearance and eye position.
·         Look for any asymmetry or abnormality of facial form.
·         Eyes:
·         Establish that they are of normal shape and appearance.
·         Check for presence of red reflex.
·         Look for obvious cataracts or signs of ophthalmic infection.
·         Ears:
·         Note shape and size.
·         Establish whether they are set at the normal level or 'low-set'.
·         Check patency of external auditory meatus.
·         Mouth:
·         Check the colour of the mucous membrane; observe the palate.
·         Check suckling reflex by inserting a clean little finger gently inside the baby's mouth.
·         Arms and hands:
·         Establish whether they are of normal shape and moving normally.
·         Look for evidence of traction birth injury (eg, Erb's palsy) by checking the neck, shoulders and clavicles.
·         Count the fingers and observe their shape; check for any evidence of clinodactyly (incurving of fingers).
·         Check palmar creases - whether they are multiple or single. A single palmar crease may be normal, but can be a sign of Down's syndrome (trisomy 21).
·         Peripheral pulses:
·         Check brachial, radial and femoral pulses for rate, rhythm and volume.
·         A hyperdynamic pulse may suggest patent ductus arteriosus.
·         A weak pulse may occur with a congenital cardiac anomaly (impairing cardiac output and in conjunction with other signs from the examination).
·         Check for radio-femoral delay (aortic coarctation).
·         Heart:
·         Check the cardiac position by palpation and feel for any thrill or heave.
·         Listen to the heart sounds carefully and for any added sounds or murmurs.
·         Suspected abnormalities require further examination (and often more expert opinion and investigation).
·         Lungs:
·         Watch the respiratory pattern, rate and depth for a few seconds.
·         Look for any evidence of intercostal recession.
·         Listen for stridor.
·         Auscultate lung fields for added sounds.
·         Abdomen:
·         Look at abdominal girth and shape.
·         Carefully check the umbilical stump for infection or surrounding hernia.
·         Palpate gently for organs, masses or herniae.
·         It is common to be able to feel the liver and/or spleen in healthy newborns.
·         Check the external genitalia carefully (see the separate article on Ambiguous Genitalia).
·         Palpate for testes in boys.
·         Inspect the anus (establish whether meconium been passed).
·         Back:
·         Look carefully at the skin over the back and at the spinal curvature/symmetry.
·         Observe whether there is any evidence of spina bifida occulta or pilonidal sinus hidden by flesh creases or dimples.
·         Palpate the spine gently.
·         Hips:
·         Specifically test for congenital dislocation of the hip (aka congenital hip dysplasia) using a combination of Barlow and Ortolani manoeuvres (follow the link for more detail).
·         Legs:
·         Watch movements at each joint.
·         Check for any evidence of talipes equinovarus.
·         Count toes and check their shape.
·         CNS:
·         Observe tone, behaviour, movements and posture.
·         Elicit newborn reflexes only if there is cause for concern.
·         Further examination should be conducted as necessary according to any abnormalities that are detected, or suspicions of undetected illness in the baby.
Record findings
·         Always document the findings of the examination in the postnatal care plan and personal child health record. A proforma for the examination, kept within the notes, can save time and act as a prompt to ensure that no element of the examination is missed.
Other screening tests
·         NICE recommends that newborn screening tests, as currently advised by the UK National Screening Committee, should be offered to all UK-born children.
·         This includes the newborn heel prick blood spot test traditionally used to pick upphenylketonuria and hypothyroidism. The blood spot, or heel prick, test is taken between 5 and 8 days ((ideally at day 5, count date of birth as day 0). It may include tests for other metabolic abnormalities in future:
·         Sickle cell disease: all newborn babies in England are offered screening for sickle cell disease.[1] 
·         Cystic fibrosis: biochemical screening is offered to all newborn babies.[1] 
·         Medium-chain acyl CoA dehydrogenase (MCAD): the Department of Health introduced routine MCAD deficiency screening in the neonatal blood spot test from February 2009.[1] 
·         The routine neonatal screening examination should be repeated at 6-8 weeks and an assessment of visual fixation and social smiling conducted.
·         hearing screen should be completed before discharge from hospital (or by week 4 in the hospital programme/week 5 in the community programme).
·         Problems in Small Babies
·         Benign Congenital Hypotonia
·         Read more articles 
Common abnormalities detected in the newborn screening examination
·         Capillary or macular haemangioma:
·         Also known as stork mark/bites, or salmon patch; found around the eyes and nape of the neck in 30-50% of babies.
·         Those around eyes normally disappear in first year, and commonly persist if on the nape of the neck.
·         Blue-black pigmented area:
·         Also known as Mongolian blue spots; they are seen at the base of the back and on the buttocks. These are common in dark-skinned parents but can occur in Caucasian infants.
·         They normally disappear over the first year.
·         Urticaria of the newborn:
·         This is most evident on day 2 as a fluctuating, widespread erythematous rash with a raised white/cream dot at the centre of a red flare, mostly apparent on the trunk.
·         This disappears spontaneously without treatment.
·         Heat rash:
·         Also known as miliaria, this may appear as either red, macular patches or superficial, clear vesicles that are most marked on the forehead and around the neck.
·         It is associated with warm humid environments and will clear in cooler, drier conditions.
·         Breast enlargement:
·         Seen in both girls and boys; the child may secrete a small amount of milk ('witches milk').
·         This is thought to be due to response to circulating maternal hormones.
·         It is not significant unless the condition persists/progresses.
·         White pimples:
·         Also known as milia; they are seen on the nose and cheeks and are found in approximately 40% of newborns, due to blocked sebaceous glands.
·         These clear spontaneously.
·         Oral cysts:
·         These are found on the palate near the midline and on the gums (also known as Epstein's pearls).
·         They may be larger and on the floor of the mouth.
·         They usually resolve spontaneously.
·         Teeth can be present at birth (no action is required unless they are loose or abnormal, in which case they may have to be extracted).
·         Accessory skin tags:
·         Seen on the face as accessory auricles anterior to the ears.
·         They can be dealt with easily by a surgical team.
·         Vestigial extra digits:
·         These can usually be dealt with easily by a surgical team.
·         Sacral dimples:
·         These are common.
·         Examine carefully to detect underlying sinus or evidence of spina bifida occulta.
·         Deformity of the shape of the head in the immediate postnatal period and following days is common:
·         Such 'moulding' is non-pathological and usually resolves spontaneously.
·         Assess whether there are any other craniofacial abnormalities.
·         Seek expert input if unsure.
Abnormalities that may indicate a significant underlying cause
·         Any wide separation of the fontanelles, with presence of islands of bone (Wormian bones) may indicate cranial abnormalities caused by a range of congenital syndromes.
·         A third fontanelle, found between the normal anterior and posterior fontanelles may indicate Down's syndrome.
·         Abnormally shaped or placed ears may indicate fetal alcohol syndrome, craniofacial abnormalities due to abnormal branchial arch development or conditions such asEdward's syndrome (trisomy 18) or congenital renal anomalies.
·         Single palmar crease can indicate Down's syndrome but may be found in children who do not suffer from this condition.
·         Abnormalities of the face, jaw and ears are often associated with hearing dysfunction; hearing tests should be performed and ENT assessment requested.




149. Secondary powerless labor.

Secondary uterine inertia occurs after adequate uterine contractions and manifests by decreasing of uterine contractions strength, duration and frequency  later.
Secondary uterine inertia as a rule is presented in the end of the cervical stage of labor and in the pelvic stage. Its frequency is 2,4 % to all number of labor. The causes of secondary uterine inertia are the same, as primary uterine inertia has had. But, as a rule, secondary uterine inertia is more common as a result of:
·               “cephalopelvic disproportion” in clinic contracted pelvis, hydrocephalia, fetal malpresentations, transversus and oblique fetal lies, tumors in true pelvis;
·                     “unripe” uterine cervix, its scar’s changes;
·                     vaginal stenosis;
·                     breech presentation;
·                     expressed pain in uterine contractions;
·                     inadequate usage of  amniotomy;
·                     endometritis;
·                     administration of excess and inadequate anesthesia, uterotonic and spasmolytics drugs. 
It is very important to differentiate secondary uterine inertia with “cephalopelvic” disproportion for preventing obstetric complications. Arrest of descent over a 2 hour-period is suggestive of either “cephalopelvic” disproportion or ineffective uterine contractions.

150. Clinic and management of premature delivery.
Preterm labour (PTL)

DEFINITION Onset of labour prior to 37 weeks gestation.

AETIOLOGY May be idiopathic. Infection (often subclinical) contributes increasingly to
aetiology with decreasing gestation. See pathology/pathogenesis below.

ASSOCIATIONS/RISK FACTORS Infection of genital tract, UTI, multiple pregnancy,
polyhydramnios, cervical incompetence/previous cervical surgery, systemic infective illness,
previous PTL, uterine abnormalities, APH.

EPIDEMIOLOGY Affects 6% of deliveries in the UK.

HISTORY Regular painful contractions, although may present as diffuse pains or cramping. ?
PV bleed, ?SROM.

EXAMINATION
General: Signs of infection (tachycardia, fever).
Abdomen: Contractions, abdominal tenderness (may indicate abruption, chorioamnionitis).
Speculum: ?liquor pooling.
Vaginal: Assess cervical dilatation.

PATHOLOGY/PATHOGENESIS Relationship with systemic infective illness may be due to
direct spread of infection or release of inflammatory mediators. Decidual haemorrhage is
also associated with release of inflammatory mediators. PTL in polyhydramnios/multiple
pregnancy is related to uterine over-distension.

INVESTIGATIONS
Bloods: FBC, CRP (evidence of infection).
Microbiology: MSU, LVS/HVS.
CTG: Fetal wellbeing.
USS: Confirm presentation, estimated fetal weight, cervical length.
Fetal fibronectin: (Sample taken at speculum examination) predictive of likelihood to labour
(used for high negative predictive value).

MANAGEMENT Administer steroids (fetal lung maturation), tocolysis used to allow steroid
cover e.g. oxytocin antagonists (atosiban), nifedipine or GTN (contraindicated if APH or
evidence of infection), antibiotics if SROM, fetal monitoring.

COMPLICATIONS Respiratory distress syndrome, intracranial haemorrhage, sepsis,
necrotising enterocolitis, neurodevelopmental delay, cerebral palsy, neonatal death.

PROGNOSIS Dependent on gestation at delivery, accounts for over 20% of perinatal
mortality. There is 20% risk of PTL in subsequent pregnancies


151. Dyscoordinated labor activity.
INCOORDINATIVE UTERINE ACTIVITY is characterized by absence adequate coordinate  uterine contractions between different uterine parts: right and left its sides, upper and lower uterine parts, different its regions. Its frequency is         1-3 %.
The main causes of incoordinate uterine contractions are:
· uterine abnormality;
· uterine cervix dystocia;
· flat amniotic sac;
· impairment of uterine innervating;
· damaging of uterine regions as a result of inflammatory, degenerative and neoplastic changes.
Incoordinative uterine activity is characterized by painful, irregular and  frequent uterine contractions. “Unripe” cervix and slow its dilation, preterm rupture of amniotic fluid, flat amniotic sac is common. Presenting part is movable or fixated to the pelvic inlet for a long period of time. Woman in labor  has been tired later and the arrest of presenting part is presented..
It is very important to differentiate incoordinative uterine activity with uterine inertia, “cephalopelvic” disproportion for different ways of these disorders management.
Management of abnormal labor in incoordinative uterine activity
Amniotomy gives good results. Uterotonic drugs are contraindicated for incoordinative uterine activity treatment.
The b-mimetics, calcium chammel blockers, magnesium sulfate, and antiprostaglandins and sedative drugs have been used to inhibit labor. Ethanol has a direct depressant effect on smooth muscle and inhibits oxytocin release. Atropine and scopolamine relax the lower uterine segment and decrease the frequency of contractions
In the case of presence maternal exhaustion, therapeutic rest is indicated. In the case of “cephalopelvic” disproportion cesarean section is performed.


152. Amniotomy (indications, technique).

indications
Induction or augmentation of labour, with or without a Syntocinon infusion
ƒ To apply a scalp electrode for foetal monitoring
ƒ To take foetal lactate/pH
ƒ Assessment of liquor in presence of abnormal foetal heart rate
ƒ Non-reassuring CTG

technique




153. Hydatidiform mole. Clinic, diagnostic, management.
Gestational trophoblastic disease (hydatidiform mole)
DEFINITION Benign tumour of trophoblastic tissue.

AETIOLOGY Abnormal fertilisation.
Complete moles: Diploid and paternal in origin with no fetal tissue, usually arise from
duplication of haploid sperm after fertilisation of an empty ovum, or from dispermic
fertilisation of an empty ovum.
Partial moles: Triploid with two sets of paternal haploid genes and one set of maternal
haploid genes following dispermic fertilisation of an ovum, may contain fetal parts or fetal
red blood cells.

ASSOCIATIONS/RISK FACTORS See Gestational trophoblastic malignancy.

EPIDEMIOLOGY Affects 1 per 1500 pregnancies (up to 1 per 200 in parts of Asia).

HISTORY PV bleeding, hyperemesis (" bHCG), symptoms of hyperthyroidism are rare (note:
often diagnosed by USS prior to symptoms).

CLINIC: Uterus larger than expected for gestational age, rarely signs of
hyperthyroidism ("bHCG mimics TSH).

PATHOLOGY/PATHOGENESIS
Macro: Grape-like appearance in complete moles, partial moles may contain recognisable
fetal tissue.
Micro: Hydropic villi, atypical hyperplastic trophoblasts in complete moles, focal villi swelling
and trophoblastic hyperplasia in partial moles.

INVESTIGATIONS
Bloods: bHCG grossly elevated.
Imaging: Pelvic USS (snowstorm appearance, vesicles/cysts).

MANAGEMENT
Surgical: ERPC (avoid uterotonics owing to possibility of dissemination).
Monitoring: Serial monitoring of bHCG in specialist centre (in UK: Charing Cross, Sheffield,
Dundee), methotrexate if rising/stagnant bHCG levels, avoid pregnancy until 6 months
of normal bHCG levels.

COMPLICATIONS Progression to malignancy (15–20% complete moles, 2–3% partial
moles).

PROGNOSIS Risk of recurrence is 1–2%. After two or more molar pregnancies, recurrence
risk is 17%.

154. Diabetes mellitus and pregnancy.

Diabetes may complicate a pregnancy either because
a woman has pre-existing insulin-dependent diabetes
mellitus (IDDM) or non-insulin-dependent diabetes
mellitus (NIDDM) before pregnancy or because she
develops usually transient impaired glucose tolerance
or diabetes during the course of her pregnancy(Gestational diabetes).

Effects of pregnancy on diabetes
• Change in eating pattern
• Increase in insulin dose requirements
• Greater importance of tight glucose control
• Increased risk of severe hypoglycaemia
• Risk of deterioration of pre-existing retinopathy
• Risk of deterioration of established nephropathy
Effects of diabetes on pregnancy
• Increased risk of miscarriage
• Risk of congenital malformation
• Risk of macrosomia
• Increased risk of pre-eclampsia
• Increased risk of stillbirth
• Increased risk of infection
• Increased operative delivery rate

Management in pregnancy
The aim of treatment is to maintain blood glucose
levels as near normal as possible with a combination of
diet and insulin, and control is achieved by matching
insulin dose with food intake. Insulin doses will change
in pregnancy due to the physiological increase in
insulin resistance. Targets for therapy are to maintain
HbA1c

6 per cent, with pre-meal glucose levels at

3.5–5.5 mmol/L and 2-hour postprandial levels of
4–6.5 mmol/L. This relative normoglycaemia means
that asymptomatic hypoglycaemia can occur more
frequently. Therefore, careful self-monitoring of glucose
levels by women with diabetes is a critical aspect of care.

Obstetric management is aimed initially at
ensuring that the appropriate screening tests are
performed, including nuchal translucency scanning,
detailed ultrasound assessment for fetal anomalies
and fetal echocardiography. Serial growth scans
are recommended to detect fetal macrosomia and
polyhydramnios, although this is rarely a problem
before the third trimester. Any concern for fetal
well-being should lead to increased surveillance
with Doppler ultrasound and CTG.

155. Placenta previa: etiology, diagnostic, management.
Placenta praevia
DEFINITION A placenta wholly or partly inserting into the lower segment.

AETIOLOGY Unknown.

ASSOCIATIONS/RISK FACTORS Multiple pregnancy, "maternal age, previous uterine
surgery, previous placenta praevia, smoking.

EPIDEMIOLOGY Affects 0.5% of pregnancies.

HISTORY Usually detected on routine ultrasound. Acutely, presents with painless PV
bleeding in the second/third trimester.

EXAMINATION
General: May be shocked (tachycardia, hypotension)
Abdomen: Usually soft, non-tender, ?malpresentation.
Vaginal: Contraindicated.
Speculum: Gentle speculum examination permitted (assess bleeding).
PATHOLOGY/PATHOGENESIS Unknown. Abnormal implantation thought to occur where
blood supply disrupted (e.g. uterine scar). Bleeding occurs secondary to shearing forces.
Minor placenta praevia: Placenta close to, but not covering, internal cervical os.
Major placenta praevia: Placenta overlying internal cervical os.

INVESTIGATIONS
Bloods: FBC, U&E, clotting, X-match.
CTG: Fetal wellbeing.
USS: Confirm placental site.
MRI: May be used to determine placenta accreta (placenta adherent to uterine wall) or
placenta increta/percreta (placenta invades into or through the uterine wall).

MANAGEMENT
Vaginal delivery: Only possible if lower placental edge >2 cm from internal os and fetal
head below placenta.
Caesarean section: If no bleeding, aim for 38/40.
Mild self-limiting bleed, no fetal/maternal compromise: Admit for monitoring, steroids
if preterm, anti-D if Rhesus negative.
Severe bleed or fetal/maternal compromise: Manage as for severe placental abruption or
maternal/fetal compromise (see above).

COMPLICATIONS
Maternal: Haemorrhage (APH þ " risk PPH), DIC, hysterectomy.
Fetal: IUGR, death.

PROGNOSIS Maternal mortality is 1 per 300.
156. Pregnancy and labor after surgical treatment of heart diseases.


157. Perinatal centers.
Perinatal Center is a hospital that provides care services for pregnant women and newborns . There are 3 levels

Level 1: hospitals provide care to normal and low-risk pregnant women and newborns, and they do not operate neonatal intensive care units (NICU);
Level 2 : hospitals provide care to women and newborns at moderate risk and do operate NICUs;
Level 3 : hospitals care for patients requiring increasingly complex care and operate NICUs.


158. Amniotic fluid. Indications for amniotomy.
Amnionic fluid serves several roles during pregnancy. It creates
a physical space for fetal movement, which is necessary
for normal musculoskeletal development. It permits fetal
swallowing—essential for gastrointestinal tract development,
and fetal breathing—necessary for lung development. Amnionic
fluid guards against umbilical cord compression and protects
the fetus from trauma. It even has bacteriostatic properties.
Amnionic fluid volume abnormalities may reflect a problem
with fluid production or its circulation, such as underlying fetal
or placental pathology. These volume extremes may be associated
with increased risks for adverse pregnancy outcome.


159. Artificial induction of labor. Indications for induction of labor.

Indications
Induction is indicated when the benefits to either mother or
fetus outweigh those of pregnancy continuation. The more
common indications include membrane rupture without labor,
gestational hypertension, oligohydramnios, nonreassuring fetal
status, postterm pregnancy, and various maternal medical conditions such as chronic hypertension and diabetes.

Technique
Oxytocin has been used for decades to induce or augment
labor. Other effective methods include prostaglandins, such
as misoprostol and dinoprostone, and mechanical methods
that encompass stripping of membranes, artificial rupture of
membranes, extraamnionic saline infusion, transcervical balloons,
and hygroscopic cervical dilators. Importantly, and as
recommended in Guidelines for Perinatal Care, each obstetrical
department should have its own written protocols that
describe administration of these methods for labor induction
and augmentation (American Academy of Pediatrics
and American College of Obstetricians and Gynecologists,
2012).

160. Role of female dispensary in prevention of gestosis.



 


 Head of obstetrics and gynecology chair L.V. Gutikova

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